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Albumin preparation: what it is, instructions for use and use during pregnancy, composition and photo

  1. Composition and release form
  2. pharmachologic effect
  3. Indications for use
  4. Contraindications
  5. Dosing and Administration Albumin
  6. Side effects
  7. Drug interactions

Albumin - what is it Albumin - what is it? This is an albumin protein solution, which is isolated from human plasma and is a clear, viscous white liquid. It is used for intravenous administration in the treatment of shock conditions. Albumin is intended for parenteral nutrition and is a partial substitute for blood plasma. Let us consider in more detail the composition, release form of Albumin, instructions for use of this drug.

Composition and release form


The drug is presented in the form of 5, 10 and 20% solution for infusion , which is produced in glass bottles or ampoules. Bottles with a solution should be hermetically sealed with rubber stoppers. Both ampoules and bottles are placed in carton packs, and the ampoule packaging is supplemented with an ampoule knife.

The composition of albumin is the main active ingredient - human albumin protein, which is isolated from blood plasma. In addition, the drug Albumin composition supplemented with excipients: sodium caprylic acid, sodium chloride , water for injections .

pharmachologic effect



The active ingredient helps to transport many substances in the body The active ingredient helps to transport many substances in the body. Necessary compounds, as well as toxins that are subject to utilization, enter into a reversible interaction with these blood proteins, and then are transported to the organ in which they will then be processed.

Albumin protein is needed to regulate such an important indicator as oncotic blood pressure. In addition, it eliminates the deficiency of plasma albumin and leads to a rapid increase in the volume of circulating blood.

Indications for use

The drug Albumin indications for use has the following:

  • liver disease;
  • nephrotic syndrome in nephritis;
  • severe burns, accompanied by thickening of the blood and dehydration;
  • hypoproteinemia and hypoalbuminemia;
  • hypovolemic, hemorrhagic, operative, purulent-septic, toxic and traumatic shock;
  • swelling of the brain;
  • therapeutic plasma exchange, hemodialysis;
  • ascites;
  • gastrointestinal tract diseases;
  • hemolytic disease and hyperbilirubinemia in newborns.

In addition, this drug is prescribed for operations accompanied by artificial blood circulation, during hemodilution before surgery and the preparation of autologous blood components. It is inappropriate to use the product in chronic nephrosis, because Albumin does not have time to exert its effect on renal damage, since the kidneys eliminate it immediately.

The drug human albumin in acute nephrosis is used quite rarely. The use of infusions as a protein source for patients suffering from cirrhosis, pancreatitis, and intestinal absorption is not justified.

Contraindications

Human albumin can not be taken with the following diseases:

With caution, the drug should be taken in the suppression of heart function, since it is likely that acute heart failure will develop. As indicated in the instructions, it increases blood pressure. Therefore, after its infusion after injuries and operations, bleeding from damaged vessels, which due to low pressure have not previously been bleeding, often opens.

The drug cannot be used if it looks cloudy and has been frozen. If the solution was not used to the end, then it can not be re-used. To prevent possible bacterial contamination, it is forbidden to use vials that have cracked, damaged, or been opened in advance.

Dosing and Administration Albumin

The solution for infusion, namely, its concentration and dosage, the doctor selects individually The solution for infusion, namely, its concentration and dosage, the doctor selects individually. It depends on body weight, injury, the severity of the disease and the loss of fluid and protein.

According to the instructions for use, the drug must be administered intravenously . The recommended single dose for a 5% solution is 200-300 ml, and the maximum allowable amount is 500-800 ml.

Usually the doctor prescribes a 10% solution of the drug. The average dose is calculated according to the following formula: 1-2 ml / kg. The agent is administered intravenously every day or every other day until a positive result is achieved. Twenty percent solution is used in severe cases. It can not be used for elderly patients.

It is important to control the rate of infusion, because its rapid introduction can disrupt the function of the cardiovascular system.

During pregnancy, albumin can only be used according to the strict indications of the doctor , since there is no reliable information about how the drug affects the fetus.

Side effects

When using the drug side effects usually do not occur.

In previously sensitized individuals, side effects can manifest themselves in the form of allergic reactions: shortness of breath, urticaria, chills, tachycardia, lowering blood pressure, fever, pain in the lumbar region, anaphylactic shock. In addition, people who are at risk are prone to complications and allergies. These are patients, in the history of which there is evidence that they do not tolerate intravenous infusions of vaccines, plasma substitutes, drug serums and drugs.

If reactions or complications occur, stop the infusion of the solution immediately. The needle should not be removed, and it is urgent to introduce cardiotonic antihistamines, glucocorticoids, vasopressor products, if there are necessary indications.

Drug interactions

Simultaneous use of phenylbutazone, barbiturama, penicillin, salicylates and sulfonamide with human albumin reduces the effectiveness of the latter Simultaneous use of phenylbutazone, barbiturama, penicillin, salicylates and sulfonamide with human albumin reduces the effectiveness of the latter.

Albumen may be combined with red blood cell mass, whole blood, carbohydrate and electrolyte solutions. The drug should not be mixed with solutions of amino acids, alcohol-containing agents and protein hydrolyzates.

Thus, human Albumin , the photo of which is presented in the article, in some cases can save a person’s life. But it should be remembered that this drug has contraindications and side effects, in addition, it is very expensive. Its counterparts are able to partially solve this problem, since they are not much cheaper .

Drug albumin